Core Outcome Measures in Effectiveness Trials

Research projects

Development of core outcome sets for informed consent and clinical trials of colorectal cancer surgery

Supervisors: Professor JM Blazeby MD FRCS; Dr ST Brookes PhD; Dr K Avery PhD; Mr AGK McNair PhD MRCS
Research Fellow: Mr RN Whistance MRCS

This project aims to develop a core outcome set for surgery for colorectal cancer. Click here to view more study details.


A systematic review to collate the knowledge base for core outcome set development

Supervisor: Professor Paula Williamson, University of Liverpool
PhD student:  Miss Elizabeth Gargon

As part of the COMET Initiative we are developing an internet-based resource to collate the knowledge base for core outcome set development, as well as the applied work that has already been done according to disease area. It will include planned and ongoing work as well as published accounts of core outcome set development. Keeping the database up to date is key to its value for users. This requires the development and application of an optimal, multi-faceted search strategy to identify work related to the development of core outcome sets (COS). Click here to view more study details.


Head and neck cancer: defining core outcome sets for clinical trials

Supervisors: Dr Terry Jones and Dr Catrin Tudur-Smith; University of Liverpool
Research fellow: Aoife Waters

Issues of biological heterogeneity, incidence of post-treatment functional deficits and relatively small numbers provide challenges when deciding on outcomes for RCTs in patients with SCCHN.


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