Core Outcome Measures in Effectiveness Trials

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The COMET (Core Outcome Measures in Effectiveness Trials) Initiative brings together people interested in the development and application of agreed standardised sets of outcomes, known as ‘core outcome sets’. These sets represent the minimum that should be measured and reported in all clinical trials of a specific condition, and are also suitable for use in clinical audit or research other than randomised trials. The existence or use of a core outcome set does not imply that outcomes in a particular trial should be restricted to those in the relevant core outcome set. Rather, there is an expectation that the core outcomes will be collected and reported, making it easier for the results of trials to be compared, contrasted and combined as appropriate; while researchers continue to explore other outcomes as well. COMET aims to collate and stimulate relevant resources, both applied and methodological, to facilitate exchange of ideas and information, and to foster methodological research in this area.

When searching the COMET database, please note that a systematic review is currently underway to identify eligible material, and we are continually updating the database as we identify eligible studies. Therefore, the records retrieved by any search might increase on a daily basis.


The COMET database currently contains 571 references of planned, ongoing and completed work.

The keyword used for the search will be compared with study title, abstract and author's surname.

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Core resource pack


Useful references for core outcome set developers.

This includes an overview of the problems with outcomes in trials, key issues to consider in the development of a core outcome set, examples of core outcome set development, and things to think about once a COS is agreed. To read more, click here.

Latest News

  • Monday 01 December, 2014 - Report from the COMET IV meeting Rome 19-21st Nov 2014 by Duncan Barron

    Duncan Barron - a blog post about the conference, the reasons for developing Core Outcome Sets (COS) and some of the presentations. Read the blog here.

  • Monday 24 November, 2014 - Summary for ESO Masterclass on Systematic Reviews in Cancer Care, Guidelines and Research

    A rainy day in Belfast. It doesn’t require a systematic review to conclude that that’s not unusual, but that’s how Saturday 7 June 2014 began, the first day of this European School of Oncology (ESO) inaugural Masterclass on the role of systematic reviews in cancer. Over the next five days of intense but enjoyable work, we moved on from the rain and overcast skies to glorious sunshine and warmth. Our hope was that the 27 participants from 15 countries would also develop a brighter outlook, with more illumination on issues around the conduct and use of systematic reviews. Read the full article here

  • Monday 24 November, 2014 - COMET IV - Ricerca clinica. Esperti riuniti a Roma per migliorare i trial del futuro

    Nella conferenza finanziata dalla Comunità europea che si terrà presso la Pontificia Università Lateranense, verranno discussi i limiti delle attuali ricerche cliniche, in particolare dei trial clinici randomizzati e delle revisioni sistematiche e meta-analisi, e verranno ridefinite le regole chiave per migliorare l’utilità della ricerca clinica e aumentarne le ricadute.

    http://www.quotidianosanita.it/scienza-e-farmaci/articolo.php?articolo_id=24380

Recently Added Studies

  • A core outcome set for clinical trials in acute diarrhea

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  • Outcome reporting in bariatric surgery: an in-depth analysis to inform the development of a core outcome set, the BARIACT Study

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  • Outcomes Important to Patients Public and Practitioners (OMIPPP): Rhinosinusitis

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  • Outcomes Important to Patients Public and Practitioners (OMIPPP): Breastfeeding

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  • Outcomes Important to Patients Public and Practitioners (OMIPPP): Asthma

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