Core Outcome Measures in Effectiveness Trials

REGISTRATION FOR THE COMET VI MEETING IS NOW OPEN
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The COMET (Core Outcome Measures in Effectiveness Trials) Initiative brings together people interested in the development and application of agreed standardised sets of outcomes, known as ‘core outcome sets’ (COS). These sets represent the minimum that should be measured and reported in all clinical trials of a specific condition, and are also suitable for use in clinical audit or research other than randomised trials. The existence or use of a core outcome set does not imply that outcomes in a particular trial should be restricted to those in the relevant core outcome set. Rather, there is an expectation that the core outcomes will be collected and reported, making it easier for the results of trials to be compared, contrasted and combined as appropriate; while researchers continue to explore other outcomes as well. COMET aims to collate and stimulate relevant resources, both applied and methodological, to facilitate exchange of ideas and information, and to foster methodological research in this area.

When searching the COMET database, please note that a systematic review is currently underway to identify eligible material, and we are continually updating the database as we identify eligible studies. Therefore, the records retrieved by any search might increase on a daily basis.


The COMET database currently contains 812 references of planned, ongoing and completed work.

The keyword used for the search will be compared with study title, abstract and author's surname.

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To view a demonstration of how to search the COMET database click here

Core resource pack


Useful references for core outcome set developers.

This includes an overview of the problems with outcomes in trials, key issues to consider in the development of a core outcome set, examples of core outcome set development, and things to think about once a COS is agreed. To read more, click here.

Latest News

  • Thursday 30 June, 2016 - COMET VI registration now open

    We are pleased to announce that registration for COMET VI is now open. You can register here.

    You can also submit an abstract for presentation at COMET VI.

    We look forward to seeing you in Amsterdam.

  • Monday 29 February, 2016 - COMET VI Save the date

    We are pleased to announce that COMET VI will take place on Thursday 10th and Friday 11th November 2016, in Amsterdam.

    The venue name is Rode Hoed (it means red hat and is named after the hat makers that were there before the church was built).

    More details and registration to follow, but for now SAVE THE DATE!

  • Monday 25 January, 2016 - Core outcome sets and systematic reviews

    Systematic reviews seek to bring together research evidence to answer the question for the review. The reviewers usually wish to compare, contrast and, if appropriate, combine the findings of the existing research studies. However, these intentions are often thwarted by inconsistencies in the outcomes that were measured and reported in the individual studies. This, in turn, makes it difficult for readers of the review to use it to make informed decisions and choices about health and social care. One solution is for trials in a particular topic area to measure and report a standardised set of outcomes, which would then be used in the review. Core outcome sets are a means of doing this. Read the full commentary here.

Recently Added Studies

  • Developing a Core Outcome Set for evaluating self-management interventions in people with comorbid diabetes and severe mental illness

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  • Stroke Recovery and Rehabilitation Roundtable (SRRR): consensus development for core measures in rehabilitation/recovery clinical trials

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  • Combining nutrition and exercise to optimize survival and recovery from critical illness: Conceptual and methodological issues

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  • Which outcomes are most important to people with aphasia and their families? an international nominal group technique study framed within the ICF

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  • ICHOM: Paediatric overall health

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